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Pseudo-cushing's syndrome
Elevated levels of total cortisol can also be due to estrogen found in oral contraceptive pills that contain a mixture of estrogen and progesterone. Estrogen can cause an increase of cortisol binding globulin and thereby cause the total cortisol level to be elevated. However, the total free cortisol, which is the active hormone in the body, as measured by a 24 hour urine collection for urinary free cortisol, is normal.

Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6. It is an alpha-globulin.

Binding

Transcortin binds several steroid hormones:
Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.
Progesterone
Aldosterone
11-Deoxycorticosterone (DOC)

Production

Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.

I thought some steroids lower SBHG?

Also upon looking at my tests my iron transferrin saturation is 65. top of the range is 45. This indicates hemochromotosis. My cousin has this so it could be in the family. It is a common problem in Caucasians.

I saw one paper that stated various hemocrological diseases resulted in high levels of transcortin. The only other thing that seems increase transcortin is estrogen.

Iron is a slow killer, I really need to get my iron down

It is also linked to low libido and impotence. : http://www.ncbi.nlm.nih.gov/pubmed/885326

Iron - 29.1 umol/L (5.0 - 30.0)
Transferrin * g/l 1.9 (2.0 - 3.2)
TBIC * 44 (47 - 70)
Saturation % 66 (10-45)
Ferritin 164 ug/L (30-300)

The saturation is the important number over 60. This indicates fairly severe iron overload.

Also something else that is concerning is my platelets have fallen below range.

148 (150-450) last year they were 152.

My bili Total has gone up a little 17 ( 4-20) was 15 last year

The only things I can find that increase transcortin are estrogen and hematological disorders.

I really hope my liver is not screwed?

Maybe a screwed up liver could explain higher estrogens and why arimidex fixed me for a few days?

I swear I am experiencing low cortisol symptoms. I got a doc to write a test for transcortin. I will do this in the next couple of days.

Something weird has been happening. I have been feeling aroused in dreams, this happens at the time where I get nocturnal wood. - My morning wood is no good.

Iron deposits in the pituitary gland and testicles cause shrinkage of the testicles and impotence. Iron deposits in the pancreas cause a decrease in insulin production resulting in diabetes mellitus (please read the Diabetes Mellitus article). Iron deposits in the heart muscle can cause heart failure as well as abnormal heart rhythms. Iron accumulation in the liver causes scarring of the liver (cirrhosis) and an increased risk of developing liver cancer. For further information on the consequences of cirrhosis, please read the Cirrhosis article.

Yes I am reading a book on iron overload now. It is full of scientific references. Having too much iron in your tissues slowley destroys all your organs and kills you. Gives you cancer, heart disease cancer, diabeties, alzimers. It is very important to have your iron levels in optimal range for good health.

The most effective treatment for hemochromatosis is to reduce iron in the body by phlebotomy (withdrawal of blood from the arm veins). One unit of blood, which contains 250 mg of iron, usually is withdrawn every one to two weeks. Serum ferritin and transferrin saturation are checked every two to three months. Once ferritin levels are below 50 ng/ml and transferrin saturations are below 50%, the frequency of phlebotomies are reduced to every two to three months. When hemochromatosis is diagnosed early and is treated effectively, damage to the liver, heart, testicles, pancreas and joints can be prevented completely, and patients maintain normal health. In patients with established cirrhosis, effective treatment can improve the function of the heart, skin color, and diabetes; however, the cirrhosis is irreversible and the risk of developing liver cancer remains.

The benefits of therapeutic phlebotomy in hemochromatosis are as follows:

It prevents the development of liver cirrhosis and liver cancer if the disease is discovered and treated early.
It improves liver function partially in patients who have already developed advanced cirrhosis.
It improves and/or completely resolves symptoms of weakness, liver pain, joint pain, and fatigue.
It improves function of the heart in patients with mild and early heart disease.

CBG is similar to SHBG in function but it focuses on corticosteroids cortisol, progesterone, aldosterone, & DOC. It's regulated by estrogen.

(...)

Has anyone researched this and is there a way to suppress it like SHBG?

Yes, I have found links to an increase in SBHG in people with liver problems. Also patients which have cirrosis also may also have low/high transcortin.

i see wow. i had no idea this was a part of the puzzle as well. have you considered this type of treatment I posted below?

http://www.medicinenet.com/iron_overload/page4.htm