I put the link in my original post--that's at least where i read it.
The link you provided -- http://health.ezineseeker.com/how-does- ... b96b3.html
-- is not from a scientific resource. It's from "Rob Hawkins", some anonymous Internet author. This article is in fact an AD for the author's hairloss treatment products. Note the bit towards the end of article:
"Visit my website today to learn more about a cure for hair loss with these natural substances that is excellent for promoting new hair growth and optimum health.
Author Description :
Discover the best natural hair loss treatment available today. Rob Hawkins is a dedicated researcher of nutrition, diet and hair loss issues that affect both men and women. Take a moment to visit his site now at http://hairloss-solutions-site.com to learn about a new natural remedy that he recently discovered
Clicking the link above takes you to a landing page. Clicking "learn more about this new natural hair loss remedy" at bottom of THAT page takes you to http://www.provillus.com/
, one of the biggest SCAMS in the hair loss community, as it is simply a bunch of herbs one can buy off the shelf -- http://www.provillus.com/int/men/ingredients.php
My point is, YOU have taken the above SPAM article as scientific fact. That is where the error in judgement lies.
Minoxidil is NOT A DHT INHIBITOR. This is confirmed in numerous scientific papers, and organizations such as the Mayo Clinic -- http://www.mayoclinicproceedings.com/co ... 6.abstract
("Two US Food and Drug Administration-approved hair-loss pharmacotherapies—the potassium channel opener minoxidil
and the dihydrotestosterone synthesis inhibitor finasteride").
http://archderm.highwire.org/cgi/conten ... t/123/1/59Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster
"Little is known about the mechanism of action of minoxidil-induced hair growth in male pattern baldness. We studied the potential antiandrogenic effect of topical minoxidil administered at the same dose and in the same vehicle that has been used successfully clinically in human subjects on the androgen-dependent cutaneous structures of the flank organ of the golden Syrian hamster. Minoxidil applied topically to one flank organ had no androgenic effect. Neither 1% nor 5% minoxidil topically applied for three weeks prevented the androgen-dependent growth of the pigmented spot, the sebaceous gland, or the hair follicle diameter induced by subcutaneous Silastic capsules filled with crystalline testosterone. As a positive control in the same experiments, 5% progesterone did significantly inhibit pigment and sebaceous gland enlargement. We conclude that there is no antiandrogenic component to the mechanism of action of topical minoxidil in the hamster flank organ, and thus there is probably no antiandrogenic role in man either
Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalphttp://www.jdsjournal.com/article/S0923-1811(98
"Minoxidil is known to induce hair growth in male pattern baldness, for which development androgen plays a central role. We studied the effect of minoxidil on testosterone metabolism by cultured dermal papilla cells from balding or nonbalding scalp and dermal fibroblasts. In all three groups, 17β-hydroxysteroid dehydrogenase activity was much higher than 5α-reductase activity. Minoxidil increased 17β-hydroxysteroid dehydrogenase activity by nearly 40% (P<0.001) in dermal papilla cells of balding scalp, whereas the effect was less marked in dermal papilla cells from nonbalding scalp and dermal fibroblasts. 5α-Reductase activity was also slightly increased by minoxidil in dermal papilla cells from balding scalp
. Again, the effect on 5α-reductase activity was insignificant in the other two groups of cells. Whether such modification of testosterone metabolism in dermal papilla cells of balding scalp by minoxidil is related to its therapeutic effect remains unknown."
Knowing this, you do NOT suffer from the same mechanisms which caused Finasteride-induced permanent symptoms. I'm sorry you are suffering from problems, but because both drugs work completely differently, treatment of your problem will likely focus on a much different set of targets. You need to investigate more how Minoxidil works if you want to get help from the doctor -- for example, I've already provided info regarding effects on blood pressure. Changes in blood pressure can affect erectile function.
Also, the link you put up to argue against it, well that on that same site that same doctor replied to another user who complained about suffering from the sexual side effects of rogaine. He basically told the user that its impossible for rogaine to cause sexual side effects. Its like all us former minox users who are complaining about this are just making stuff up? I don't believe that doctor is very credible.
Did you neglect to read the link I provided PRIOR to the baldingblog one? Here it is again -- http://www.drugbank.ca/drugs/DB00350
That doctor, while he may dismiss numerous permanent side effects from Finasteride use, and possibly Minoxidil use, is only quoting from literature which we are also referencing. The scientific literature I have read thus far does NOT state Minox acts as a DHT inhibitor, rather that it is a potassium channel opener. You need to either provide documented scientific papers that corroborate your belief (not SPAM blogs), or accept this fact.
You don't seem very welcoming, I apologize for being so burdensome to you and your site you man. The only reason I posted here is because my problems are caused by another hair growth med.
Honestly, I and the moderators had the choice to APPROVE or DISAPPROVE your post before it was even made, since we moderate all new users. We decided to let you post considering your story. However, now I can see this has been a mistake, for reasons already mentioned -- you do not fit the demographic of this site and hence enabling those who have not taken a 5AR inhibitor to post, often stirs up controversy and wastes everyone's time in the end. I'm not trying to offend you with that comment but honestly, so far all you've done is argue based on false facts in the first place, and counter various useful advice given thus far with excuses.
Again, my side effects are EXACTLY like what people on here are going through--that's why I came here.
The title of this forum is Propeciahelp. It's content is related to 5ARI inhibition. Minoxidil is not a 5AR inhibitor. Ergo, a forum dedicated to Minoxidil related issues is your best bet. We are not attempting to cast the net wide to include all people with sexual dysfunction from various medications, as JN put it, otherwise this site would be a general sexual dysfunction website. While I sympathise with the fact you are experiencing similar side effects as users here report, the fact is you took a completely unrelated medication and thus the root cause of your problems will be different.
I had absolutely NONE of these problems until I started on the Rogaine.
Hence why you should seek out experts and forums on Minoxidil use. We are NOT those men.
And I have posted on other sites, but have had little feedback.
I'm sorry then... perhaps consider finding more sites to post on, or create your own forum and website for permanent Minoxidil side effects to connect with others experiencing same?
Good I am glad someone else has also read about its DHT inhibiting effects. That link I posted wasnt the only place Ive read about it, Ive just generally heard about it blocking DHT in the past, thats what I was under the impression it did to stop hair loss.
Again, neither of you has provided scientific evidence to backup this concept. Until proven otherwise, Minox is well known to operate as a potassium channel opender and vasodilator, not a DHT inhibitor.
Whatever it did it has messed me up badly, and unfortunately the effects feel like they could be permanent. Im not trying to take away from the quality of this site, but I cant help that minox has had the same effects on me.
Sorry to hear that, but again -- besides the blood test suggestions, not sure what else we can offer you to investigate. I recommend you do some serious reading on Google Scholar and Google Books to better understand Minoxidil's mechanisms of action, so you can hopefully find the source of your issues with a doctor's help.