PROPECIAHELP: Persistent Finasteride Propecia Proscar side effects info & discussion forum

It is 30 time more potent than cortisol. 0,5mg is too low to generate side effects. 0,5mg Dexamethason is equal to appr. 15mg Cortsol. Endogen production is appr. 40-60mg daily. 0,5mg Dexa is within this range so there are no side effects.

attached find the original paper referring to androgen metabolism and dexamethasone.
maybe of interst for somebody.
in the meantime i got contact with the authors about the creatine study.
they are pretty sure that 5alpha reductase is mediating the observed effect. they have no idea which isoform nor which tissue. anyways - creatine has been linked with hair loss (controversial but reported by some users), so in this regard it might be in our favour- don't know.
it might be worth looking further to creatine since i know there will be a reply (comment, letter to the editor?) to the original creatine publication.

Just letting you guys know that i'm gonna stoped taking quircetin a few days ago. I'll be seeing a doctor on friday and he's going to order some blood tests for me and i don't want to be taking anything when the tests are taken that could influence the test results.

Ok, this might sound stupid, but I did some research regarding dexamethasone because last night I said "screw it" and took .25 of Dex. I cut the standard .5mg pill in have, took it, and went to sleep. Well, I slept all night with a good erection, similar to pre-fin time wise (most all night consistent wood) but slightly less than pre-fin intensity wise. It was hard, but not throbbing hurting hard like old pre-fin days, but hard enough to feel good about it. I remember it getting hard while laying down before falling completly asleep. Well in the morning it was still hard and had to do the “leaning over take a piss routine” (something I completely forgot about since taking properia/avodart) in the morning, just like pre-fin days. Now, the intensity wasn’t throbbing hard, but it was good enough. After about 5 mins of waking time and jumping in the shower, it slowly subsided.
Well, at work today I noticed that my mind was more clear than normal. Now, for the last two weeks I have been doing a PCT which consist of Arimidex, Nolvadex, Inhibit-e and blue up. So I figure that my T should be higher than normal, which I feel it is through the normal high T signs and symptoms, and estrogen should be kept in check. So I did some research this morning because I remember Dex increase 5AR activity, but wasn’t quite sure.
Now, I’m not sure, but it appears the CTGF increases 5AR activity and Dex increases CTGF expression. So perhaps with my high T because of the PCT I’m on, and using Dex before bed, Dex might have stimulated 5AR, and 5AR had plenty of T to work with - just a guess. I’m going to try it again tonight of course, but so far its feeling pretty good, not normal of course, but it’s feeling better. Maybe a 2 month long PCT with low dose Dex might help.
Here is my “research”...I could be wrong with the “research” which doesn’t bother me because I’m feeling better.

http://www.jbc.org/content/273/29/18185.full Dexamethasone  CTFG TFG Beta 1  5AR induction

Dexamethasone simulates CTFG “dexamethasone treatment resulted in a strong induction of CTGF mRNA expression. Maximal induction was seen as early as 1 h after addition of the steroid, and increased CTGF mRNA levels were still observed after 10 h.”

CTFG TFG Beta 1, 2 simulate 5AR http://www.ihop-net.org/UniPub/iHOP/pm/ ... id=7796940


Glucocorticoids Induce Angiotensin-Converting Enzyme Expression in Vascular Smooth Muscle http://hyper.ahajournals.org/cgi/content/short/25/3/343
Glucocorticoids (dexamethasone)  Angiotensin  TFG Beta  5AR
“In response to the glucocorticoid dexamethasone (100 nmol/L for 72 hours), ACE activity (hydrolysis of [3H]benzoyl-Phe-Ala-Pro) increased 10.1±3.1-fold.”

Aginotensin stimulates TFG Beta
http://ajpregu.physiology.org/cgi/conte ... 278/3/R640

very interesting...are you taking .5mg of dex per day ...or 2x a week type of deal?

Well.. I only took .25 (half a pill) last night. I'm going to take another .25 tonight and take it from there. We'll have to see. I'm thinking as long as it continues to stay positive take it with this PCT I'm doing.

Keep us updated please..Thanks

I took another .25 dexamethasone last night, and this morning felt more cleared headed; however, I noticed that the boys is more flaccid, thin, and floppy, as if I was on fin again, which is weird. I feel mentally better, had a great sleeping nocturnal erection again which lasted all night, but the boys are not hanging high. They have fallen low again..weird. I’ll continue to monitor. Maybe I should do every other night. But, needless to say, I feel mentally clearer.

That's ok...just remember dexamethasone 1/2 life is 36-48 hours....I wouldn't take too much...Start off with low dose and see if you have to adjust...this is positive news...

Why has the thread gone dead. I have spend the last few hours reading and it seemed to have ended i am going to try the protocals listed.

agreed ^, what a sad conclusion to all that reading lol

I know that others have tried this drug without success, but I'll give it a shot and see what happens.

guys seriously, u need to keep posting your experiences especially if something did not work anymore/did work.

Is there anybody else with succes with dexamethasone? Who has tried it over a longer time?

Would also like to know...

Also, just to confirm, no one had any success with Quercetin?