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PostPosted: Sun Oct 14, 2007 6:28 pm 
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Thought the following may be of interest since REM sleep (or lack thereof) is often mentioned around here... looks like Tryptophan and Serotonin are involved. Note: Milk contains Tryptophan... drink a glass before you go to bed!
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http://sleepdisorders.about.com/od/slee ... rition.htm

Foods that promote sleep include leafy green vegetables, rich in chlorophyll, whole grain breads and cereals and mushrooms. Fruits, especially berries, help with sleep problems. Even spices, including dill sage, and basil.

The time-honored remedy of a glass of warm milk at bedtime, is still a common method to aid sleep. Milk contains tryptophan, and tryptophan is converted into serotonin, the hormone that controls sleep. Other foods containing tryptophan are honey, turkey, egg whites and tuna, all good as night time snacks.

Other supplements include melatonin, a hormone secreted by the pineal gland that induces sleep. Tryptophan, mentioned above as a component of milk and other foods. Tryptophan is an amino acid and ix converted into serotonin. 5-HTP (5-hydroxytryptophan) increases REM sleep and increases the deep sleep stages of sleep.



Bed-time food supplements and sleep: effects of different carbohydrate levels.
http://www.ncbi.nlm.nih.gov/sites/entre ... t=Citation

"Blood glucose levels were altered during sleep by means of manipulating carbohydrate (CHO) intake through bed-time food supplements.

...A high CHO condition resulted in significantly reduced stages 1 + 0 sleep over the whole night and significantly increased REM sleep during the first half of the night.

It was concluded that relatively high blood glucose levels were required to alter sleep, and perhaps lead to more 'restful' sleep. The REM sleep changes were discussed in relation to increases in brain serotonin synthesis mediated by elevated blood glucose levels.


Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects.
http://www.ncbi.nlm.nih.gov/sites/entre ... t=Citation

"After tryptophan depletion but not placebo, significant effects on sleep EEG were observed in terms of decreased non-rapid eye movement (non-REM) stage 2, increase of wake %, and of rapid eye movement (REM) density compared with baseline. REM latency was not altered, however the first and second REM period interval were significantly shorter after tryptophan depletion. This study underlines the impact of the serotonergic system on sleep maintenance and on REM sleep."


Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications
http://jcem.endojournals.org/cgi/content/full/88/5/2087

We conclude that in healthy adults, age-related alterations in nocturnal wake time and daytime sleepiness are associated with elevations of both plasma IL-6 and cortisol concentrations, but REM sleep decline with age is primarily associated with cortisol increases.


Mid-morning Tryptophan Depletion Delays REM Sleep Onset in Healthy Subjects
http://www.nature.com/npp/journal/v27/n ... 5948a.html

"Because serotonin is involved in the diachronic regulation of sleep, we tested the effect of a midmorning rapid deficiency in the serotonin precursor tryptophan on the next night's sleep.

"... The results show that midmorning RTD (rapid tryptophan depletion) delays REM sleep latency during following night-time sleep, whereas evening RTD shortens REM sleep latency in previous studies, and suggest that the serotonin control of REM sleep latency is upregulated."


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PostPosted: Sun Oct 14, 2007 8:48 pm 
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So, I'm a little lost...
Eat lots of turkey, tuna, milk (although I think its bad for the prostate), and honey, because its all high in Tryptophan, to sleep better with more REM sleep.
Is that it?

Whats that about higher blood glucose levels??


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PostPosted: Thu Sep 18, 2008 3:43 am 
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Tryptophan's sedative effects are plausible at best.

I quote:

Quote:
But Tryptophan doesn't act on the brain unless it's on an empty stomach, with no protein present, and the amount gobbled even during a holiday feast is generally too small to have an appreciable effect.


http://www.snopes.com/food/ingredient/turkey.asp

Another link:
http://www.cfsan.fda.gov/~dms/ds-tryp1.html


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PostPosted: Wed Nov 26, 2008 7:39 am 
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very interesting, thanks!


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