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notworthit
 Post subject: Isotretinoin and FOX01
PostPosted: Wed Aug 10, 2011 7:46 am 
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Location: Australia
http://www.acne.org/messageboard/post-a37337-.html
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bluecloud87
PostPosted: Wed Aug 10, 2011 8:03 am 
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?
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notworthit
PostPosted: Wed Aug 10, 2011 8:18 am 
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You don't understand the article ?
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bluecloud87
PostPosted: Wed Aug 10, 2011 8:23 am 
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I barely read it, can you break it down? why is it relevant?
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notworthit
PostPosted: Wed Aug 10, 2011 8:35 am 
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UK20 wrote:
I barely read it, can you break it down quickly?


Sure, it's saying that FOXO transcription factors are crucial regulatory proteins:

Quote:
Forkhead box O (FoxO) transcription factors FoxO1, FoxO3a,
FoxO4 and FoxO6 are important regulatory proteins that modulate
the expression of genes involved in cell cycle control, DNA
damage repair, apoptosis, oxidative stress, cell differentiation,
glucose metabolism, inflammation, immune functions and regulation
of stem cell homeostasis.14


In a nutshell, isotretinoin fiddles with the aforementioned transcription factors to the detriment of the patient on the poison.

Quote:
The proposed isotretinoin→ATRA→RAR→FoxO
interaction offers intriguing new insights into the mode of
isotretinoin action and explains most therapeutic, adverse and
teratogenic effects of isotretinoin in the treatment of acne by
a common mode of FoxO-mediated transcriptional regulation.
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Dubya_B
PostPosted: Wed Aug 10, 2011 9:22 pm 
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Age: 30
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Started: 0- 8-1998
Stopped: 0- 8-1999
Location: Pittsburgh, PA, US
This section of the study really caught my eye: "Isotretinoin, FoxO1 and Suppression
of Androgen Receptor Transactivation"

There was another section that discussed how it could effect the limbic system. (possible cause of emotional blunting?)

Thank you very much for posting this notworthit.

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notworthit
PostPosted: Thu Aug 11, 2011 1:47 am 
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Yes, I stumbed upon it over at acne. org. I might take it down though, because I think it irks some members. I think I am still being quizzed on it.
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bluecloud87
PostPosted: Thu Aug 11, 2011 1:52 am 
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I am not irked on it at all, i just struggled to understand it that's all. Keep extracting what you can from it.
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notworthit
PostPosted: Thu Aug 11, 2011 2:13 am 
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Pull the other one: it's all there in the subheading for all to see. All we talk about here is suppression of the androgen receptor (not knocking it, just noting the facts), which can be caused by yellow jelly beans, amongst other things; so, how could anyone miss the relevance ?
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notworthit
PostPosted: Thu Aug 11, 2011 2:26 am 
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For the record, I am not implying that you are in anyway silly. You could have easily understood the article. For eveyone else: I am not usually such a bitch - I think it's quenched androgen receptor signal.
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