PROPECIAHELP: Unresolved Finasteride Propecia Proscar side effects info & discussion forum

Here are my blood tests from Sept/2008.They are not converted to american.I believe they are all in SI units.

Free Testosterone- 99(24-75)pmol/L

Total Testosterone - 34 (10-30)nmol/L

Dihydrotestosterone- >8600 (800-3400)pmol/L (H)..Wow off the charts eh!

SHBG- 13 (13-71)nmol/L

Estradiol-17 BETA - 293 HI (43-151) pmol/L

Progesterone- 2 (<4) nmol/L

FSH - <1 LO (2-8) IU/L

LH - <1 LO (2-6) IU/L

DHEA-S - 2.9 (2.6-14.4) umol/L

Cortisol AM - 401 AM(170-720) nmol/L

Cortisol PM - 61 PM(up to 1/2 of patients AM value)

Cortisol 24 HR URINE - 190 HI (27-180) NMOL/D


My LH and FSH are low or unexistant,no doubt because I've been on TRT for the last 4 years at 120mgs/week. I just started taking HCG-300 IU 3X weekly and arimidex 0.25 mg 3x weekly.

My next step is to have urinary tests done through Rhein,Quest or Labcort and the 3-alpha-G-diol to see whether the high DHT is consistent in the urine and that I have good 5AR 2 activity. Although I believe 70% of DHT production is via isoenzyme 2 activity. Isn't that right Mew?

Thanks for any help and advice in advance.

With T and DHT levels like that, you should be feeling like superman, have erections like steel and be a raging horndog day and night.

However...

Estradiol-17 BETA - 293 HI (43-151) pmol/L

Clearly Estradiol is OUT OF RANGE high and needs to be brought down (hence the Arimidex?) Perhaps if this is brought under control you may feel improvements. You may want to test Estrone, Estriol and Total Estrogens as well.

Have you felt ANY change between stopping Finasteride and then starting TRT 4 years ago (ie, has TRT helped with libido, erections, shrinkage etc)?


DHEA-S - 2.9 (2.6-14.4) umol/L

DHEA-S seems unusually low for a man of your age, though not sure if taking TRT would cause this? This likely points to an adrenal steroid metabolism issue.


Cortisol 24 HR URINE - 190 HI (27-180) NMOL/D

Seems your body is producing too much cortisol? Again, points to the adrenals.

- Consider investigating adrenal function further (ie, Cushing's Disease) and testing various hydroxysteroid pathways: http://www.caresfoundation.org/productc ... s_cah.html




Yes, 5AR2 contributes ~70% of DHT
5AR1 contributes ~30% of DHT

http://www.pubmedcentral.nih.gov/articl ... gure&id=F2


Although, even in 5AR2 deficient pseudohermaphrodites that have a 5AR2 enzyme mutation, 5AR1 can still contribute enough to serum DHT levels such that DHT is still detectable within normal ranges. Scroll down for screenshots on this concept:
http://www.propeciahelp.com/forum/viewt ... =5838#5838

... and hence why getting 3a-androstanediol glucuronide testing is important, which may or may not validate our theories on wether 5AR2 has been permanently "deactivated": http://www.propeciahelp.com/forum/viewtopic.php?t=761