PROPECIAHELP: Persistent Finasteride Propecia Proscar side effects info & forum

Info and forum for men with PERSISTENT sexual, mental and physical side effects which CONTINUE DESPITE QUITTING hair loss & prostate drug Finasteride Propecia, Proscar

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Symptoms of the Post-Finasteride Syndrome, permanent Propecia side effects

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The majority of Finasteride-related side effects are synonymous with androgen deprivation therapy -- in this case, androgen deprivation by taking a 5ARI inhibitor (Finasteride) and reducing DHT, the most potent male androgen.



adt-symptoms adt-symptoms2

 

Post-Finasteride / 5ARI Syndrome - Timeline

The below common hypogonadal symptoms affect the vast majority of men who experience the Post-Finasteride Syndrome. Onset of symptoms may manifest while on the drug (Propecia or Proscar), but typically follows a common pattern whereby:

  1. Within 10-14 days of quitting there is a surge/return of DHT in the body (as 5AR2 is supposedly no longer inhibited by Finasteride)
  2. Brief resolution of side effects (as the manufacturer claims should occur) takes place over the following week (days 15-21).
  3. Unfortunately this androgen surge and resolution of symptoms is short-lived, as the feelings/effects of androgen (DHT) returning to the body begin to fade over the next few days/weeks.
  4. Concurrent with this ebbing away of androgenic action is an "endocrine system crash", followed by return of symptoms in full-force and worsening of the patient's condition -- including complete loss of libido, penile/scrotal atrophy, and host of other side effects.
  5. Bloodwork at this stage often reveals a massive decrease in endogeneous Testosterone, LH and FSH production, often to hypogonadal levels along with numerous other hormone imbalances.

The reason(s) for this adverse post-drug reaction, and why treatments designed to restore androgenic action in these men often meet with little to variable success, remains unknown.

 

Post-Finasteride / 5ARI Syndrome - Symptoms Legend:

Post-drug: symptoms start to manifest within weeks of quitting drug (typically when Testosterone levels drop)
On drug + post-drug: symptoms manifested while on drug

Sexual

 

Physical

 

Neurological

Libido

  • Loss of libido/sexual desire, never horny
  • No more sexual thoughts, fantasies
  • Nothing "turns you on" or "happens in your head" in response to sexual stimuli
  • Loss of sexual dreams during sleep

Erections

  • Erectile dysfunction, impotence
  • Loss of morning erections
  • Loss of spontaneous erections
  • Loss of nocturnal erections

Penis

  • Penile atrophy (length, girth)
  • Fibrotic penile tissue changes
  • Wrinkled, constantly retracting into body
  • Cold penis, decreased bloodflow
  • Rubbery texture, loss of sensitivity
  • Significant twisting/rotation on axis

Scrotum

  • Empty, saggy, loss of fullness
  • Shrunken, constantly retracting into body
  • Cold scrotum, decreased bloodflow
  • Rubbery texture, loss of sensitivity
  • White scrotal hairs, decreased scrotal hair

Ejaculate

  • Decreased ejaculate volume
  • Decreased ejaculate force
  • Watery ejaculate
  • Ejaculate consistency & color changes

Orgasm

  • Loss of nocturnal emissions
  • Weak orgasm, no longer pleasureable
  • Ejaculations while flaccid
  • Premature ejaculation
  • Increased refractory period
 

Feminization

  • Gynecomastia (male breasts)
  • Female fat distribution patterns
  • Female pubic hair pattern
  • Feminine hips, buttocks, chest/stomach
  • Feminine hands, arms & legs

Muscle

  • Body-wide muscle twitches (fasciculations)
  • Significant muscle loss: fingers, hands, wrists, forearms; calves, legs, thighs

Pain

  • Testicular, epididymis and prostate pain

Fatigue

  • Chronic fatigue; no energy, always tired
  • Loss of stamina, frequent exhaustion

Androgenicity

  • No more acne, oil or sebum production
  • Extremely dry skin

Metabolism

  • Decreased body temperature
 

Memory

  • Severe memory/recall impairment
  • Constant forgetfulness, blanking out

Cognition

  • Decreased acuity, comprehension
  • Slowed thought processes, fogginess
  • Difficulty processing information
  • Impaired problem solving

Speech

  • Impaired tongue motor control
  • Slurring of speech, stuttering

Sleep

  • Disrupted sleep/wake cycle
  • Loss of REM sleep (dreams)
  • Constant waking throughout night, often gasping for breath

Emotion

  • Emotional blunting, flatness
  • Loss of excitement, pleasureable feelings

Drive

  • Loss of ambition, motivation
  • Loss of aggression, passiveness

Depression

  • Severe depression, hopelessness
  • Feelings of sadness, melancholy

Anxiety

  • Anxiety, paranoia
  • Severe panic attacks


Last Updated on Wednesday, 04 July 2012 03:48  

Donate to PFS Foundation

The Post-Finasteride Syndrome Foundation is dedicated to helping fund research into the characterization, underlying biologic mechanisms of and treatments for Post-Finasteride Syndrome (PFS).

If you or a loved one are suffering from persistent Finasteride side effects, please donate towards research into PFS today.

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