PROPECIAHELP: Persistent Finasteride Propecia Proscar side effects info & forum

Info and forum for men with PERSISTENT sexual, mental and physical side effects which CONTINUE DESPITE QUITTING hair loss & prostate drug Finasteride Propecia, Proscar

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Symptoms of the Post-Finasteride Syndrome, permanent Propecia side effects


The majority of Finasteride-related side effects are synonymous with androgen deprivation therapy -- in this case, androgen deprivation by taking a 5ARI inhibitor (Finasteride) and reducing DHT, the most potent male androgen.

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Post-Finasteride / 5ARI Syndrome - Timeline

The below common hypogonadal symptoms affect the vast majority of men who experience the Post-Finasteride Syndrome. Onset of symptoms may manifest while on the drug (Propecia or Proscar), but typically follows a common pattern whereby:

  1. Within 10-14 days of quitting there is a surge/return of DHT in the body (as 5AR2 is supposedly no longer inhibited by Finasteride)
  2. Brief resolution of side effects (as the manufacturer claims should occur) takes place over the following week (days 15-21).
  3. Unfortunately this androgen surge and resolution of symptoms is short-lived, as the feelings/effects of androgen (DHT) returning to the body begin to fade over the next few days/weeks.
  4. Concurrent with this ebbing away of androgenic action is an "endocrine system crash", followed by return of symptoms in full-force and worsening of the patient's condition -- including complete loss of libido, penile/scrotal atrophy, and host of other side effects.
  5. Bloodwork at this stage often reveals a massive decrease in endogeneous Testosterone, LH and FSH production, often to hypogonadal levels along with numerous other hormone imbalances.

The reason(s) for this adverse post-drug reaction, and why treatments designed to restore androgenic action in these men often meet with little to variable success, remains unknown.


Post-Finasteride / 5ARI Syndrome - Symptoms Legend:

Post-drug: symptoms start to manifest within weeks of quitting drug (typically when Testosterone levels drop)
On drug + post-drug: symptoms manifested while on drug







  • Loss of libido/sexual desire, never horny
  • No more sexual thoughts, fantasies
  • Nothing "turns you on" or "happens in your head" in response to sexual stimuli
  • Loss of sexual dreams during sleep


  • Erectile dysfunction, impotence
  • Loss of morning erections
  • Loss of spontaneous erections
  • Loss of nocturnal erections


  • Penile atrophy (length, girth)
  • Fibrotic penile tissue changes
  • Wrinkled, constantly retracting into body
  • Cold penis, decreased bloodflow
  • Rubbery texture, loss of sensitivity
  • Significant twisting/rotation on axis


  • Empty, saggy, loss of fullness
  • Shrunken, constantly retracting into body
  • Cold scrotum, decreased bloodflow
  • Rubbery texture, loss of sensitivity
  • White scrotal hairs, decreased scrotal hair


  • Decreased ejaculate volume
  • Decreased ejaculate force
  • Watery ejaculate
  • Ejaculate consistency & color changes


  • Loss of nocturnal emissions
  • Weak orgasm, no longer pleasureable
  • Ejaculations while flaccid
  • Premature ejaculation
  • Increased refractory period


  • Gynecomastia (male breasts)
  • Female fat distribution patterns
  • Female pubic hair pattern
  • Feminine hips, buttocks, chest/stomach
  • Feminine hands, arms & legs


  • Body-wide muscle twitches (fasciculations)
  • Significant muscle loss: fingers, hands, wrists, forearms; calves, legs, thighs


  • Testicular, epididymis and prostate pain


  • Chronic fatigue; no energy, always tired
  • Loss of stamina, frequent exhaustion


  • No more acne, oil or sebum production
  • Extremely dry skin


  • Decreased body temperature


  • Severe memory/recall impairment
  • Constant forgetfulness, blanking out


  • Decreased acuity, comprehension
  • Slowed thought processes, fogginess
  • Difficulty processing information
  • Impaired problem solving


  • Impaired tongue motor control
  • Slurring of speech, stuttering


  • Disrupted sleep/wake cycle
  • Loss of REM sleep (dreams)
  • Constant waking throughout night, often gasping for breath


  • Emotional blunting, flatness
  • Loss of excitement, pleasureable feelings


  • Loss of ambition, motivation
  • Loss of aggression, passiveness


  • Severe depression, hopelessness
  • Feelings of sadness, melancholy


  • Anxiety, paranoia
  • Severe panic attacks

Last Updated on Wednesday, 04 July 2012 03:48  

Donate to PFS Foundation

The Post-Finasteride Syndrome Foundation is dedicated to helping fund research into the characterization, underlying biologic mechanisms of and treatments for Post-Finasteride Syndrome (PFS).

If you or a loved one are suffering from persistent Finasteride side effects, please donate towards research into PFS today.

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