The Post-Finasteride Syndrome (PFS)

PFS describes a life-altering condition that can develop in a subset of men following exposure to the 5-alpha reductase inhibitor Finasteride (Propecia)

About this site is a website and discussion forum for men suffering persistent sexual, mental & physical effects after taking the drug Finasteride

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The site and discussion forum exists to support and connect men affected by the Post-Finasteride Syndrome

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Memory disorders “significantly associated” with isotretinoin and antidepressant use

Memory disorders “significantly associated” with SSRI and isotretinoin use Memory disorders and related problems are a key concern of members.  French researchers, publishing in the British Journal of Clinical Pharmacology, have found that both isotretinoin and antidepressants are  significantly associated with memory disorders:…

Accutane: Journalist seeks interviewees for isotretinoin side effects research, UK issues drug safety update and Cosmo magazine covers devastating persistent effects

Accutane (isotretinoin) shares potent 5-alpha reductase inhibiting properties with finasteride and can cause a syndrome that can be apparently identical to Post Finasteride Syndrome. Reported persistent effects include libido loss, erectile dysfunction, depression, suicidal ideation, anxiety, panic attacks, penile shrinkage,…

Latest Forum Topics

  • Blocked ejaculation?! Anyone have this?
    by @Cooper on January 19, 2019 at 1:34 am

    @Cooper wrote: I just tried to masturbate and when i came, there was a clog like feel, just under my two testicles where Pelvic Floor muscles starts. I had this thing time to time but this time it happened more severe. My muscles try to push out the […]

  • Is Oleanide safe to take with Mirtazapine
    by @Shellnyce on January 18, 2019 at 5:12 pm

    @Shellnyce wrote: I have been doing some research on other sleep aids. While searching for Phenibut info I came across Oleanide. Would this be safe to take if I"m already on Mirtazapine. I know that with drugs like Trazodone, you risk Seratonin […]

  • Question about 5a-DHT (dark side article)
    by @Rmoney96 on January 18, 2019 at 7:48 am

    @Rmoney96 wrote: “Administration of 5α-DHT with or without the 5α-RIs, restored sexual behavior in long-term castrated male rats suggesting a critical role for 5α-DHT in erectile physiology.” When we take proviron is that […]

  • Can GnRH agonist meds like leuprorelin cause PFS like symptoms?
    by @spstriken on January 18, 2019 at 1:37 am

    @spstriken wrote: Do you think that GnRh agonist can cause the same sides as pfs? I don’t think so. this question about the use of leuprorelin in profile page? looks like leuprorelin sides are not […]

  • 4 Months Off...Still Suffering
    by @stillhope on January 18, 2019 at 12:30 am

    @stillhope wrote: First off, I appreciate all the support on this forum and I have been following it for the last three months and this is my first post. I took finasteride from late May to late September and stopped taking it in late September when I […]

Latest Research

  • Post-finasteride syndrome – does it really exist?
    Related Articles Post-finasteride syndrome – does it really exist? Aging Male. 2019 Jan 16;:1-10 Authors: Maksym RB, Kajdy A, Rabijewski M Abstract Inhibitors of 5α-steroid reductase are drugs used to …
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