Post-Androgen Deprivation Syndrome
Diverse substances capable of anti-androgenic endocrine disruption including 5alpha reductase inhibitors, isotretinoin, serotonergic antidepressants, saw palmetto extract and concentrated phenolic compounds marketed as health supplements are causing a severe syndrome in some consumers. The administrators of propeciahelp have provided a literature review and mechanistic hypothesis to inform further clinical research.
Blog
New publication reports penile vascular abnormalities in the majority of Post-Finasteride Syndrome patients
In a newly released publication, a clinical study at the Baylor College of Medicine reported penile vascular abnormalities in the majority of PFS patients.
A word on Covid-19
Dear members, As you are all aware the world has entered a very uncertain period due to the Covid-19 pandemic. The novel coronavirus is presenting a serious challenge to the healthcare systems of advanced countries, and the safety of the…
A Post-Androgen Deprivation Syndrome: A literature review
Some patients develop persistent and severe multisystemic health problems following exposure to the 5 alpha reductase inhibitor finasteride. Serious and permanent harm is not correlated positively to exposure and can follow as little as one dose. This has been termed…
New publications focus attention on devastating consequences of PFS
Two new publications centred on PFS have been published, and serve to highlight many of the urgent challenges faced clinically and scientifically in adequately addressing the condition. Finasteride and Suicide: A postmarketing case series Writing in Dermatology, Professor Irwig carefully…
Round-up of 2019 – We Got Good Work Done Together
2019 was an important year for Propeciahelp.com and our forum contributors. Here’s a quick round-up of our three key achievements: Relaunch of Propeciahelp.com We’ve gone from a website largely dormant and with low use of the forum – to a revamped website,…
Guerrilla Patient Group Publishes Data Insights into Post-Drug Syndrome
The reports are steady. The stories are raw and difficult. The problem of lasting physical, sexual and neuro-cognitive health damage from mass market medication has been known about for years. Yet doctors continue to fail their patients and have no idea how to…
Latest Research
- Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands
CONCLUSIONS: PSSD impact includes sexual, psychological, and social consequences. Little is known about the mechanisms underlying PSSD and no effective treatment exists. It is necessary to increase re … - Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin
CONCLUSIONS: These criteria will help in both clinical and research settings. As with all criteria, they will likely need modification in the light of developments. - Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors
CONCLUSION: There is a need for well-designed neurobiological research in this domain, as well as in the prevalence, pathophysiology, and treatment of PSSD. Practitioners should be alert to the distin … - The connection of 5-alpha reductase inhibitors to the development of depression
Recent literature connects 5-alpha reductase inhibitors (5-ARIs) with neuropsychiatric adverse effects. Several clinical studies have indicated that former 5-ARIs users had a higher incidence of depre … - Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?
Selective serotonin reuptake inhibitor (SSRI) drugs, targeting serotonin transport, are widely used. A puzzling and biomedically important phenomenon concerns the persistent sexual dysfunction followi …