The Post-Finasteride Syndrome (PFS)

PFS describes a life-altering condition that can develop in a subset of men following exposure to the 5-alpha reductase inhibitor Finasteride (Propecia)

About this site is a website and discussion forum for men suffering persistent sexual, mental & physical effects after taking the drug Finasteride

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The site and discussion forum exists to support and connect men affected by the Post-Finasteride Syndrome

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Accutane: Journalist seeks interviewees for isotretinoin side effects research, UK issues drug safety update and Cosmo magazine covers devastating persistent effects

July 9, 2018 - Accutane (isotretinoin) shares potent 5-alpha reductase inhibiting properties with finasteride and can cause a syndrome that can be apparently identical to Post Finasteride Syndrome. Reported persistent effects include libido loss, erectile dysfunction, depression, suicidal ideation, anxiety, panic attacks, penile shrinkage, gynecomastia, muscle atrophy, cognitive impairment, insomnia, severely dry skin and tinnitus. The condition often has a radical and extreme impact - Continue Reading »

Relaunch of

May 19, 2018 - Welcome to both long term sufferers of PFS and new members. Propeciahelp has now undergone a substantial update. This change was necessary from a technical perspective, but also for a number of reasons relating to user experience, including the accommodation of mobile devices. We hope that you find the new design pleasant and easy to navigate. As well as a - Continue Reading »

Ongoing research into PFS

May 19, 2018 - PFS is a variable and potentially devastating condition, but its molecular mechanism(s) are currently unclear. The predispositions that cause a subset of men to develop PFS from as little as a single exposure to a 5-alpha reductase inhibitor remain unknown. Reported symptoms include (but are not limited to) loss of libido, erectile dysfunction, suicidal ideation, depression, anxiety, panic attacks, cognitive - Continue Reading »

Latest Forum Topics

  • Do you drink alcohol?
    by @Greek on July 16, 2018 at 4:38 am

    @Greek wrote: Do you drink alcohol? Does it have a positive/negative/any effect on your condition? Posts: 3 Participants: 2 Read full topic […]

  • Frequent urination/urinary incontinence is driving me crazy
    by @Wings on July 16, 2018 at 4:02 am

    @Wings wrote: I made a post a few months back about having frequent urination. I’ve had it for about a year now. I always have to get up at night to go. I almost always feel like I have to pee. When I do go, not 10-20 minutes later do I have […]

  • What do we “know” about Pfs?
    by @jjbunch on July 16, 2018 at 1:47 am

    @jjbunch wrote: I’ve seen posts about overexpresion, posts about auto immunity, gene expression. Is there anything we KNOW about our condition at this point? Posts: 3 Participants: 3 Read full topic […]

  • Antidepressants that don't induce 3α-HSD
    by @borax on July 15, 2018 at 8:26 pm

    @borax wrote: I was wondering if anyone is aware of antidepressants that DON’T induce 3α-HSD (which lowers androgens on a cellular level). I’ve been on Buproprion for close to 2 years at this point, continuing it even after PFS as I […]

  • Getting so much worse after 100% recovered
    by @David_1986 on July 15, 2018 at 6:09 pm

    @David_1986 wrote: Hello guys, I’ve posted before aobut this, in a topic called I WAS RECOVERED. I had a crash in 2015, I recovered myself in 7 months more or less, the side effect that more lasted was ED… I had an incredible 2016, and big […]

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