The Post-Finasteride Syndrome (PFS)

PFS describes a life-altering condition that can develop in a subset of men following exposure to the 5-alpha reductase inhibitor Finasteride (Propecia)

About this site is a website and discussion forum for men suffering persistent sexual, mental & physical effects after taking the drug Finasteride

Join the Community

The site and discussion forum exists to support and connect men affected by the Post-Finasteride Syndrome

previous arrowprevious arrow
next arrownext arrow


Memory disorders “significantly associated” with isotretinoin and antidepressant use

Memory disorders “significantly associated” with SSRI and isotretinoin use Memory disorders and related problems are a key concern of members.  French researchers, publishing in the British Journal of Clinical Pharmacology, have found that both isotretinoin and antidepressants are  significantly associated with memory disorders:…

Accutane: Journalist seeks interviewees for isotretinoin side effects research, UK issues drug safety update and Elle magazine covers devastating persistent effects

Accutane (isotretinoin) shares potent 5-alpha reductase inhibiting properties with finasteride and can cause a syndrome that can be apparently identical to Post Finasteride Syndrome. Reported persistent effects include libido loss, erectile dysfunction, depression, suicidal ideation, anxiety, panic attacks, penile shrinkage,…

Latest Forum Topics

  • A very confusing and depressing story.... PLEASE HELP
    by @Baldie on August 21, 2019 at 8:00 am

    @Baldie wrote: Hello, Sorry for the weird title. I had no idea what to write. My story begins 8 years ago when my girlfriend took me to a doctor to treat my hairfall. He gave me 10% minoxidal, a shampoo and a pill. I have no idea what those pills were […]

  • Why methylation is key to recovery
    by @MasterofPuppets on August 21, 2019 at 4:48 am

    @MasterofPuppets wrote: Methyl donors such as B vitamins choline and betaine are what your liver uses to remove estrogen from your body even “estrogen blockers” will not remove estrogen from your body. (The only estrogen blockers that […]

  • Activation of the Androgen Receptor by Butyrate
    by @MOONCHILD on August 21, 2019 at 1:25 am

    @MOONCHILD wrote: Ligand-independent Activation of the Androgen Receptor by the Differentiation Agent Butyrate in Human Prostate Cancer Cells Cancer Research – 15 Oct 00 Ligand-independent Activation of the Androgen Receptor by the […]

  • Testicular microbiome
    by @guitarman01 on August 21, 2019 at 12:26 am

    @guitarman01 wrote: The study doesn’t really matter much to me atm. Its the fact that its there. this is the first study to outline that the testis holds tissue-associated commensal bacteria Testicular microbiome and dysbiosis These analyses show […]

  • Epigenetics, Gene Expression, and the Astronaut
    by @guitarman01 on August 20, 2019 at 3:59 pm

    @guitarman01 wrote: @axolotl A pretty cool, simple article looking at some of this. I also realized you werent talking about gene changes at the dna level looking back at your post. This could almost be tucked under your methylation thread. Also notice […]

Latest Research

  • Post-finasteride syndrome.
    Related Articles Post-finasteride syndrome. BMJ. 2019 Aug 09;366:l5047 Authors: Gray SL, Semla TP PMID: 31399423 [PubMed – in process]
Close Menu