Post-Finasteride Syndrome represents a Post-Androgen Deprivation Syndrome following exposure to antiandrogenic endocrine disruptors and without specificity to finasteride. The common pharmacological interruption of steroid signaling and remarkably similar clinical endpoints…
The clinical picture and molecular level understanding of PFS are not where they should be after decades of clear reports of profound suffering and suicides caused by exposure to a…
An urgent clinical failure With [humility] comes not only reverence for truth, but also proper estimation of the difficulties encountered in our search for it. …[T]his grace of humility is…
The case for diverse pathological effects arising from androgen-mediated pleiotropic mechanisms is increasingly clear beyond conditions already discussed such as PCOS and SBMA. The AR and its role in health…
Cognitive dysfunction, Anhedonia and Anxiety Anxiety, loss of motivation, loss of aggression, lack of feelings of wellbeing, severe anhedonia and visuospatial and cognitive impairment are some the most frequent neuropsychological…
Muscle atrophy and muscular dysfunction Evidence regarding the ligand- and dose-dependent atrophic consequences of AR overexpression in muscle have been discussed in a previous section. Muscle AR is a major…
Libido, erectile function, and penile structural maintenance Male libido and sexual desire is primarily androgen-mediated and strictly testosterone dependent. Considerable evidence supports libido loss as the clearest symptom of hypogonadism…
Induced Wild Type AR Overexpression and the potential relevance of SBMA to PFS As discussed, as the CAG trinucleotide sequence extends in the N-terminal domain of the AR, there is…
The AR CAG repeat polymorphism influences tissue response to androgens An increase in repeats of the cytosine-adenine-guanine (CAG) trinucleotide sequence in the N-terminal domain of the androgen receptor is inhibitory…
Endocrine disruption "Endocrine disruption" refers to a specific toxicity whereby natural and/or anthropogenic chemicals cause adverse health effects by disrupting the endogenous hormone system. An endocrine disruptor is defined by…